What Other Drugs Interact with Stevia? 2014;60(11):1003-1005. The same study also suggested nonnutritive sweeteners may induce glucose intolerance and metabolic disorders. Potential side effects linked to stevia consumption include: Stevia is considered a diuretic, meaning that it increases the speed at which the body expels water and electrolytes from the body in urine. Takasaki, M., Konoshima, T., Kozuka, M., Tokuda, H., Takayasu, J., Nishino, H., Miyakoshi, M., Mizutani, K., and Lee, K. H. Cancer preventive agents. Despite a lack of research, many people claim whole-leaf stevia is a safe alternative to its highly refined counterpart or table sugar. For example, research has shown that stevia extract may improve glucose tolerance in people with diabetes, and even in those without diabetes, according to a small study with 97 participants published in August 2018 in Contemporary Clinical Trials Communications. According to the Mayo Clinic, the U.S. Food and Drug Administration, FDA, has approved refined stevia for use as a sugar substitute; however, whole-leaf or crude extracts of stevia are not approved. If we combine this information with your protected Gastrointestinal Disturbances Associated with the Consumption of Sugar Alcohols with Special Consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals. Another popular zero-calorie sweetener issucralose, sold under the brand name Splenda. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Potential complications with the overuse of stevia products during pregnancy include: Researchers still do not understand the full range of risks associated with stevia. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, 4 milligrams (mg) per kilogram of body weight, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890837/, http://www.academia.edu/7358132/Stevia_rebaudiana_Bertoni_An_alternative_Sugar_Replacer_and_Its_Application_in_Food_Industry, https://www.ncbi.nlm.nih.gov/pubmed/26400114, https://www.fda.gov/aboutfda/transparency/basics/ucm194320.htm, http://www.academicjournals.org/journal/JMPR/article-full-text-pdf/57B2A0342160, http://www.sciencedirect.com/science/article/pii/S0924203116300157, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591507/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591507/table/Tab1/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661066/, http://www.cfp.ca/content/60/11/1003.full, http://www.sciencedirect.com/science/article/pii/S0273230016300381, http://www.sciencedirect.com/science/article/pii/S0303720716300533, http://www.internationalsteviacouncil.org/index.php?id=195, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058871, http://www.sciencedirect.com/science/article/pii/S027323001730079X. The amount of sugar alcohol that causes these symptoms varies from person to person. It has many health benefits, and may help protect against several chronic conditions. Interestingly, stevia isn't a new discovery either. Not completely carbohydrate and calorie-free (2014). U.S. Department of Agriculture. All rights reserved. Part 8: Chemopreventive effects of stevioside and related compounds. For these reasons, it may be useful for people taking steps to control . View abstract. Stevia products found on grocery store shelves, such as Truvia and Stevia in the Raw, dont contain whole stevia leaf. (2015). However, one noted limitation in this study is that it took place in a laboratory setting, rather than in a real-life situation in a persons natural environment. Prakash I, Dubois GE, Clos JF, et al. Chaturvedula, V. S. and Prakash, I. The amount of sugar alcohol that causes these symptoms varies from person to person. Certain chemicals in stevia are commonly used as natural food sweeteners. Stevia made with Reb-A is safe to use in moderation during pregnancy. The FDA says stevia glycosides, such as Reb-A, are generally recognized as safe. They havent approved whole-leaf stevia or crude stevia extract for use in processed foods and beverages due to a lack of safety information. Avicenna J Phytomed. View abstract. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. View abstract. 000252. However, some people have reported negative side effects, which include: Nausea Bloating Dizziness Numbness Muscle pain Abdominal fullness Allergic reactions such as rashes Hypotension (low blood pressure) Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Geuns, J. M., Buyse, J., Vankeirsbilck, A., and Temme, E. H. Metabolism of stevioside by healthy subjects. World Health Organization, Food and Agriculture Organization of the United Nations. CFSAN/Office of Food Additive Safety. Stevia side effects. The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Reducing sugar in your diet, and instead replacing it with other sweeteners, could potentially reduce that risk. Is the ketogenic diet right for autoimmune conditions? Stevia is used in sugar- and calorie-reduced food and beverage products as an alternative for variants with sugar. Stevia's taste has a slower onset and longer duration than that of sugar, and at high concentrations some of its extracts may have an aftertaste described as licorice -like or bitter. Both of these sweeteners are options for people who need to cut table sugar. Planta Med 2001;67(9):796-799. If youre trying to lose weight, this aspect may be appealing. It may also drop blood pressure too low or interact with medications that lower blood. Effects of the Daily Consumption of Stevia on Glucose Homeostasis, Body Weight, and Energy Intake: A Randomised Open-Label 12-Week Trial in Healthy Adults. Factors that may increase the risk of stevia side effects include: There are many different types of steviol glycoside found in stevia, classified into five major groups. Some research on long-term, daily use of artificial sweeteners suggests a link to a higher risk of stroke, heart disease and death overall. A 2013 study carried out in a laboratory found that stevia reduced cyst growth in kidney cells. Life Sci 1998;63:1679-84. While that high level of consumption is not generally recommended, it demonstrates the vast volume of stevia you would need to consume for it to be considered unsafe. So it's still unclear exactly what potential stevia side effects may occur from routine consumption of the sweetener. Study participants consumed 20 milliliters of stevia extract daily for one month. This means it has almost no calories. Daily stevia consumption may stop or slow down metabolism and so, interrupt with the conversion process of food into energy. U.S. Food and Drug Administration, December 17, 2008. Foods and drinks with aspartame can lead to serious health problems. Chan P, Xu DY, Liu JC, et al. World Health Organization. Jeppesen PB, Gregersen S, Poulsen CR, Hermansen K. Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity. Until research determines whether whole-leaf stevia is safe for everyone, get your doctors approval before using it regularly, especially if you have a serious medical condition such as diabetes, heart disease, or high blood pressure. Mayo Clinic. 2012;132(3):1121-1132. However, studies suggest that consuming sugar substitutes such as stevia in place of sugar does not have an impact on overall daily calories intake or blood sugar levels. Steviol glycosides are natural constituents of the leaves of Stevia rebaudiana (Bertoni) Bertoni, a plant native to parts of South America and commonly known as Stevia. Reb-A sweeteners are available in liquid, powder, and granulated forms. Stevia is a zero-calorie sweetener extracted from the Stevia rebaudiana plant. As with most nonnutritive sweeteners, a major downside is the taste. Some stevia products contain added sugar alcohols that may cause unpleasant symptoms in individuals that are very sensitive to the chemicals. information and will only use or disclose that information as set forth in our notice of Stevia might lower blood pressure. Tomita T, Sato N, Arai T, et al. Some people enjoy it, but its a turn-off for others. How Does Stevia Compare to Other Zero-Calorie Sweeteners? Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. We currently have no information for STEVIA overview. Taking stevia along with diabetes medications might cause blood sugar to drop too low. And that can make drinking enough water a challenge. Don't get tricked by these 3 heart-health myths, Get to know the new Nutrition Facts label, Nutrition rules that will fuel your workout, Nuts and your heart: Eating nuts for heart health. People take stevia for obesity, high blood pressure, diabetes, and many. 12-30-1984;60(12):2237-2240. By Rebecca Valdez, MS, RDN Many people choose to replace sugar with stevia to reduce their calorie consumption. Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines [Abstract]. Other brands arent made specifically for baking, so youll need to use less. They're different in the United States and Europe, for example. Nat.Prod Commun 2011;6(2):175-178. other information we have about you. Low-calorie sweeteners are often perceived as a healthful alternative to sugar, but a new study finds that they may actually increase fat formation. 2017;41(3):450-457. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. View abstract. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. More recent studies, however, have concluded that stevia may help prevent kidney damage. In a preliminary 2017 study, rats with diets comprised of up to 3.5 percent stevia for 90 days presented no clinical symptoms and experienced no change in blood chemistry, cellular function, compensation, or appearance. information submitted for this request. Because the kidney is responsible for filtering and creating urine, researchers initially thought that long-term consumption of stevia could damage the organ. Health effects of the use of non-sugar sweeteners. These can be added to foods or drinks at home. View abstract. Using sugar substitutes might make your symptoms flare up. A 2013 study supported these findings. Stamataki NS, Scott C, Elliott R, McKie S, Bosscher D, McLaughlin JT. Stamataki NS, Crooks B, Ahmed A, McLaughlin JT. If you use stevia now and then, it may not be enough to impact your blood sugar. Pepino, M. Y. Principles and methods for the risk assessment of chemicals. include protected health information. Mutagenesis 1996;11:573-9. This side effect might. Over time, it's most important to eat a healthy diet and get exercise. health information, we will treat all of that information as protected health However, stevia's safety and potential side effects have generated controversy. 2. You can grow stevia plants at home and use the leaves to sweeten foods and beverages.